PL37: a new hope in the treatment of painful diabetic neuropathy?

Treatment of painful diabetic neuropathy.

P neuropathy is one of the commonest long term complications of diabetes mellitus which has been reported to be prevalent in 22% of d iabe t i c cohor t . 1 Pa in fu l d iabe t i c neuropathy (PDN) occurs in 6% of the patients with diabetic peripheral neuropathy (DPN) and this is most distressing symptom which impairs quality of life.2 Patients seek advice to get relief but unfortunately treatm...

Venlafaxine HCl in the treatment of painful peripheral diabetic neuropathy.

In a recent letter by Davis and Smith (1), venlafaxine HCl was reported to be effective in the symptomatic treatment of patients with painful diabetic neuropathy. This observation is in accordance with a similar finding made by us. We administered venlafaxine HCl in 8 patients who had unremitting painful peripheral diabetic neuropathy that did not respond to conventional analgesia. All patients...

Painful Diabetic Neuropathy

N europathic pain exerts a substantial impact on quality of life, particularly by causing considerable interference in sleep, daily activities, and enjoyment of life. Chronic neuropathic pain is present in 13–26% of diabetic patients (1– 4). In a recent survey from Augsburg, Germany, the prevalence of painful polyneuropathy was found to be 13.3% in diabetic subjects, 8.7% in individuals with im...

Painful diabetic neuropathy.

PDN is commonly caused by involvement of either the C fibres or the Aδ fibres. PDN caused by the involvement of small nerve fibers (C fibres), may present without objective clinical findings, such as decreased peripheral reflexes or abnormalities, on routine electrophysiological studies. Small fiber neuropathies may manifest as a number of different clinical symptoms, including allodynia, burni...

Painful diabetic neuropathy pdf